D-Peptides as Recognition Molecules and Therapeutic Agents

被引：52

作者：

Liu, Min ^{[1
]}

Li, Xue ^{[1
]}

Xie, Zuoxu ^{[1
]}

Xie, Cao ^{[1
]}

Zhan, Changyou ^{[1
,2
]}

Hu, Xuefeng ^{[1
]}

Shen, Qing ^{[1
]}

Wei, Xiaoli ^{[1
]}

Su, Bingxia ^{[1
]}

Wang, Jing ^{[1
]}

Lu, Weiyue ^{[1
]}

机构：

[1] Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Dept Pharmaceut,Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China

[2] Fudan Univ, Dept Pharmacol, Sch Basic Med Sci, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL RECORD | 2016年 / 16卷 / 04期

基金：

美国国家科学基金会;

关键词：

mirror-image phage display; molecular recognition; peptides; retro-inverso; BLOOD-BRAIN-BARRIER; NATIVE CHEMICAL LIGATION; TARGETED DRUG-DELIVERY; RETRO-INVERSO-PEPTIDOMIMETICS; IMAGE PHAGE DISPLAY; MOUTH-DISEASE VIRUS; POLY(ETHYLENE GLYCOL)-CO-POLY(EPSILON-CAPROLACTONE) NANOPARTICLES; INTERSTITIAL FLUID PRESSURE; AMYLOID CASCADE HYPOTHESIS; ENDOTHELIAL GROWTH-FACTOR;

D O I：

10.1002/tcr.201600005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.

引用

页码：1772 / 1786

页数：15

共 50 条

[21] RNA-templated chemical synthesis of proapoptotic L- and D-peptides
Chang, Li-Hao
Seitz, Oliver
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 66
[22] The Ebola Virus D-Peptides are Enterotoxic Viroporins In Vivo and Potentially Druggable Targets
Guha, Shantanu
Melnik, Lilia
Ghimire, Jenisha
Smither, Allison
Wu, Eric
Sun, Leisheng
Ungerleider, Nathan
Flemington, Erik
Garry, Robert F.
Wimley, William C.
BIOPHYSICAL JOURNAL, 2020, 118 (03) : 344A - 344A
[23] Therapeutic peptides targeting intracellular molecules
Zaman, Rahela
Chowdhury, Ezharul Hoque
EUROPEAN POLYMER JOURNAL, 2024, 219
[24] Chiral separation of DL-peptides and enantioselective interactions between teicoplanin and D-peptides in capillary electrophoresis
Wan, H.
Blomberg, L. G.
Electrophoresis, 18 (06):
[25] ANTISENSE PEPTIDES - DESIGNING RECOGNITION MOLECULES
SHAI, Y
FLASHNER, M
CHAIKEN, I
JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 231 - 231
[26] Structure activity relationship study of inhibitory D-peptides against myostatin and activin A
Takayama, Kentaro
Okamoto, Hideyuki
Saitoh, Mariko
Ikekawa, Kaoru
Konno, Sho
Taguchi, Akihiro
Taniguchi, Atsuhiko
Hayashi, Yoshio
JOURNAL OF PEPTIDE SCIENCE, 2024, 30
[27] Pharmacokinetic properties of tandem D-peptides designed for treatment of Alzheimer's disease
Leithold, Leonie H. E.
Jiang, Nan
Post, Julia
Niemietz, Nicole
Schartmann, Elena
Ziehm, Tamar
Kutzsche, Janine
Shah, N. Jon
Breitkreutz, Joerg
Langen, Karl-Josef
Willuweit, Antje
Willbold, Dieter
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 89 : 31 - 38
[28] AXON SEGMENTS SPROUT AT BOTH ENDS - TRACKING GROWTH WITH FLUORESCENT D-PEPTIDES
MASON, A
MULLER, KJ
NATURE, 1982, 296 (5858) : 655 - 657
[29] MHC BINDING PEPTIDES AS THERAPEUTIC AGENTS
METZLER, B
FAIRCHILD, PJ
WRAITH, DC
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 1993, 11 : S45 - S46
[30] Peptides as Therapeutic Agents for Dengue Virus
Chew, Miaw-Fang
Poh, Keat-Seong
Poh, Chit-Laa
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2017, 14 (13): : 1342 - 1359

← 1 2 3 4 5 →