Novel class of hybrid natural products derived from lupeol as antimalarial agents

被引：28
|
作者：
Kumar, Satish
Misra, Namita
Raj, Kanwal
Srivastava, Kumkum [1 ]
Puriz, S. K. [1 ]
机构：
[1] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
NATURAL PRODUCT RESEARCH | 2008年 / 22卷 / 04期
关键词：
antimalarial; lupeol derivatives; Plasmodium falciparum;
D O I：
10.1080/14786410701766349
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Thirty-four novel hybrid lupeol derivatives (4-18) were prepared and evaluated for antimalarial activity in vitro against Plasmodium falciparum. Three compounds (13d, 16a and 17a) have shown antimalarial activity at lower dose (10 mu g mL(-1)) than lupeol.
引用
收藏
页码：305 / 319
页数：15
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