Serum bilirubin and the risk of rheumatoid arthritis

被引:16
|
作者
Du Juping [1 ]
Yuan Yuan [1 ]
Chen Shiyong [1 ]
Li Jun [1 ]
Zhou Xiuxiu [2 ]
Ying Haijian [3 ]
Shi Jianfeng [3 ]
Shen Bo [1 ,3 ]
机构
[1] Taizhou Hosp Zhejiang Prov, Dept Clin Lab, Taizhou, Zhejiang, Peoples R China
[2] Linhai City Tradit Chinese Hosp, Dept Clin Lab, Linhai, Zhejiang, Peoples R China
[3] Taizhou Hosp Zhejiang Prov, Affiliated Hosp, Dept Clin Lab, Wenzhou Med Coll, Taizhou, Zhejiang, Peoples R China
关键词
bilirubin; oxidative stress; rheumatoid arthritis; OXIDATIVE STRESS; EXPRESSION; JAUNDICE; ALBUMIN;
D O I
10.1002/jcla.22118
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
BackgroundOxidative stress and immune imbalance play an important role in the pathogenesis of rheumatoid arthritis (RA). Bilirubin is a powerful antioxidant and also regarded as immunomodulator. Increased evidence shows that bilirubin should be a protective factor for autoimmune disease. However, the relationship between bilirubin and RA remain unclear. MethodsWe analyzed serum bilirubin levels and other laboratory and clinical data in 130 RA patients (35 patients without any complications), 81 osteoarthritis (OA) patients and 96 healthy controls. ResultsBinary logistic regression adjusted by age and gender revealed that the levels of serum total, indirect bilirubin were significantly lower in RA patients, when compared with healthy controls (P=.015, OR=0.767, 95% CI=0.619-0.951; P=.010, OR=0.664, 95% CI=0.487-0.906, respectively) or OA patients (P=.000, OR=0.763, 95% CI=0.661-0.882; P=.000, OR=0.656, 95% CI=0.532-0.808, respectively). A reduced trend of levels of bilirubin has been detected along with increased disease activity, despite with no significance (P>.05). Spearman rank test further demonstrated that IgG and ESR were negative associated with total, indirect bilirubin, and albumin, prealbumin, APOA, HDL-C were positively associated with bilirubin. ConclusionsIn conclusion, the levels of serum bilirubins were decreased in RA, and decreased levels could be associated with IgG, albumin and inflammatory marker ESR.
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页数:6
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