Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles by oxidative cyclization of bisindolylmaleimides with a rhodium(III)-copper(II) catalytic system

被引：24

作者：

Witulski, B ^{[1
]}

Schweikert, T ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48143 Munster, Germany

来源：

SYNTHESIS-STUTTGART | 2005年 / 12期

关键词：

glycosides; rebeccamycin; catalysis; rhodium; copper;

D O I：

10.1055/s-2005-869977

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel catalytic protocol for the synthesis of a series of indolo[2.3-a]pyrrolo[3,4-c]carbazoles based on the bimetallic system RhCl3 center dot 3H(2)O and Cu(OAC)(2)center dot H2O in the presence of molecular oxygen was investigated. The method was applied to the synthesis of the glycosidated fluoroindolocarbazole 3 that was recently isolated as a metabolite from feeding experiments of Saccharothrix aerocolonigenes ATCC 39243 with fluorotryptophanes.

引用

页码：1959 / 1966

页数：8

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