Intermolecular Markovnikov-Selective Hydroacylation of Olefins Catalyzed by a Cationic Ruthenium-Hydride Complex

被引：26
|
作者：
Kim, Junghwa [1 ]
Yi, Chae S. [1 ]
机构：
[1] Marquette Univ, Dept Chem, Milwaukee, WI 53201 USA
来源：
ACS CATALYSIS | 2016年 / 6卷 / 05期
基金：
美国国家科学基金会;
关键词：
hydroacylation; alkene; aldehyde; ruthenium catalyst; branched ketone; ALDEHYDE OXIDATION LEVEL; C-H ALKYLATION; INTRAMOLECULAR HYDROACYLATION; BETA; GAMMA-UNSATURATED KETONES; ASYMMETRIC CATALYSIS; BOND ACTIVATION; ALCOHOLS; ALKENES; FUNCTIONALIZATION; MECHANISM;
D O I：
10.1021/acscatal.6b00856
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The cationic Ru-H complex was found to be an effective catalyst for the intermolecular hydroacylation of aryl-substituted olefins with aldehydes to form branched ketone products. The preliminary kinetic and spectroscopic studies elucidated a ruthenium-acyl complex as the key intermediate species. The catalytic method directly afforded branched ketone products in a highly regioselective manner while tolerating a number of heteroatom functional groups.
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页码：3336 / 3339
页数：4
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