The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

被引：63
|
作者：
Gal, Roland [1 ,2 ]
Deres, Laszlo [1 ,2 ]
Toth, Kalman [1 ,2 ]
Halmosi, Robert [1 ,2 ]
Habon, Tamas [1 ,2 ]
机构：
[1] Univ Pecs, Sch Med, Dept Med 1, Div Cardiol, H-7624 Pecs, Hungary
[2] Univ Pecs, Szentagothai Res Ctr, H-7624 Pecs, Hungary
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期
关键词：
resveratrol; oxidative stress; inflammation; cardiovascular diseases; heart failure; NF-KAPPA-B; VASCULAR OXIDATIVE STRESS; NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; TRANS-RESVERATROL; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; INFLAMMASOME ACTIVATION; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES;
D O I：
10.3390/ijms221810152
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective effects of natural polyphenols such as resveratrol (3,5,4-trihydroxystilbene) have been extensively investigated throughout recent decades. Many studies of RES have focused on its favorable effects on pathological conditions related to cardiovascular diseases and their risk factors. The aim of this review was to summarize the wide beneficial effects of resveratrol on the cardiovascular system, including signal transduction pathways of cell longevity, energy metabolism of cardiomyocytes or cardiac remodeling, and its anti-inflammatory and antioxidant properties. In addition, this paper discusses the significant preclinical and human clinical trials of recent years with resveratrol on cardiovascular system. Finally, we present a short overview of antiviral and anti-inflammatory properties and possible future perspectives on RES against COVID-19 in cardiovascular diseases.
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页数：22
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