Two New Anti-Tobacco Mosaic Virus Alkaloids from the Whole Plants of Thalictrum microgynum

被引：3
|
作者：
Wu, Yu-Ping [1 ,2 ,3 ]
Lin, Zhong-Long [1 ]
Zhao, Gao-Kun [1 ]
Zhou, Min [2 ,3 ]
Yao, Heng [1 ]
Zhang, Guang-Hai [1 ]
Li, Wei [1 ]
Yang, Guang-Yu [2 ,3 ]
Li, Yin-Ke [2 ,3 ]
Hu, Qiu-Fen [2 ,3 ]
Kong, Guang-Hui [1 ]
机构：
[1] Yunnan Acad Tobacco Agr Sci, Kunming 650031, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China
[3] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Yunnan, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Thalictrum microgynum; alkaloids; anti-tobacco mosaic virus (anti-TMV) activity; CONSTITUENTS;
D O I：
10.1007/s10600-022-03771-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new (1 and 2), together with four known (3-6) alkaloids were isolated from the whole plants of Thalictrum microgynum. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results indicated that compounds 2-4 showed high anti-TMV activity with inhibition rates of 34.8, 42.1, and 35.2% at a concentration of 20 mu M, respectively. These rates were higher than that of ningnanmycin, a positive control. Compounds 1, 5, and 6 also showed potential anti-TMV activity with inhibition rates of 26.7, 24.8, and 28.2%.
引用
收藏
页码：699 / 703
页数：5
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