GABAergic drugs and sexual behaviour in the rabbit:: evidence for species-specific effects

被引:4
|
作者
Paredes, RG
Contreras, JL
Ågmo, A
机构
[1] Univ Tours, Fac Sci, Psychophysiol Lab, F-37200 Tours, France
[2] Univ Anahuac, Escuela Psicol, Mexico City, DF, Mexico
[3] Univ Autonoma Estado de Morelos, Fac Ciencias Biol, Cuernavaca, Morelos, Mexico
[4] Univ Autonoma Metropolitana Iztapalapa, Dept Reprod Biol, Mexico City 09340, DF, Mexico
关键词
GABA; motor performance; rabbit; sexual behaviour;
D O I
10.1177/026988119801200211
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The effects of gamma-amino butyric acid (GABA)-ergic drugs on male rabbit sexual behaviour have been evaluated, The GABAA agonist 4,5,6,7-tetrahydroxixazolo-5,4c-pyridin-3-ol (THIP), the GABA(B) agonist R-baclofen and the GABA antagonists picrotoxin and bicuculline were used. Injection of THIP, 20 mg/kg, s.c. produced a complete suppression of sexual behaviour and R-baclofen, 2.5 mg/kg, s.c. a significant inhibition. Intraperitoneal injections produced effects at higher doses than did s.c, injections. The inhibition produced by R-baclofen was associated with strong motor effects as shown by the water escape test. It is probable, therefore, that the reduced sexual behaviour observed after treatment with this drug is a consequence of sedative or muscle relaxant effects. By contrast, the dose of THIP that inhibited sexual behaviour had no effect on the water escape test. These results show that the GABA(A) agonist inhibits sexual behaviour in the male rabbit independent of effects on the motor system. The GABA antagonists had marginal or no effects on sexual behaviour. When these data are compared to previous results in the rat, substantial differences are seen. As there are differences between the effects on rat and rabbit sexual behaviour by other types of drugs, it appears that drug action on sexual behaviour cannot be generalized from one species to another.
引用
收藏
页码:186 / 191
页数:6
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