PPARγ, 10 years later

被引：107

作者：

Lazar, MA ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Penn Diabet Ctr, Philadelphia, PA 19104 USA

来源：

BIOCHIMIE | 2005年 / 87卷 / 01期

关键词：

PPARgamma; insulin resistance; obesity; diabetes; adipocyte;

D O I：

10.1016/j.biochi.2004.10.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now over 10 years since the discovery of peroxisome proliferator activated receptor gamma (PPAR gamma) and its unique role in adipogenesis. The subsequent identification of PPAR gamma as the target of insulin sensitizing drugs certified this ligand-regulated transcription factor as an exciting link between adipocyte biology and peripheral insulin resistance. Here, I summarize the great progress that has been made over the past decade in elucidating the biology of PPAR gamma and its role in adipogenesis and glucose metabolism. Prospects for future research leading to new therapies for obesity and diabetes are also discussed. (c) 2004 Elsevier SAS. All rights reserved.

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页码：9 / 13

页数：5

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