Three-Component, Diastereoselective Synthesis of Highly Functionalized Indane Derivatives Based on an Anionic Domino Sequence from α-Nitroketones

被引：12
|
作者：
Giorgi, Giorgio [1 ]
Arroyo, Francisco J. [1 ]
Lopez-Alvarado, Pilar [1 ]
Carlos Menendez, J. [1 ]
机构：
[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain
来源：
SYNLETT | 2010年 / 16期
关键词：
carbocycles; domino reactions; nitroketones; carbanions; nitroaldol reactions; DIVERSITY-ORIENTED SYNTHESIS; POTENT INHIBITORS; CHEMISTRY; STRATEGY; PART;
D O I：
10.1055/s-0030-1258048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction between seven- or eight-membered cyclic alpha-nitroketones and aromatic 1,2-dialdehydes in the presence of DBU, with tetrahydrofuran containing some water as solvent, afforded 2-nitroindane-1,2-diols with three contiguous stereocenters, one of which is quaternary, in a one-pot, diastereoselective fashion.
引用
收藏
页码：2465 / 2467
页数：3
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