Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

被引：25

作者：

Pinana, Maria ^{[1
]}

Vila, Jorgina ^{[2
]}

Gimferrer, Laura ^{[1
]}

Valls, Maria ^{[2
]}

Andres, Cristina ^{[1
]}

Gema Codina, Maria ^{[1
]}

Ramon, Javier ^{[1
]}

Carmen Martin, Maria ^{[1
]}

Fuentes, Francisco ^{[1
]}

Saiz, Rosario ^{[1
]}

Alcubilla, Pilar ^{[1
]}

Rodrigo, Carlos ^{[2
]}

Pumarola, Tomas ^{[1
]}

Anton, Andres ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Resp Viruses Unit, Virol Sect, Microbiol Dept,Hosp Univ Vall dHebron,Vall dHebro, Barcelona, Spain

[2] Univ Autonoma Barcelona, Pediatr Hospitalizat Unit, Dept Pediat, Hosp Univ Maternoinfantil Vall dHebron, Barcelona, Spain

来源：

FUTURE MICROBIOLOGY | 2017年 / 12卷 / 07期

关键词：

duplication; evolution; genetic diversity; genotype; G protein; human metapneumovirus; molecular epidemiology; respiratory tract infection; respiratory virus; surveillance; GLYCOPROTEINS; VARIABILITY; INFECTIONS; EVOLUTION; CHILDREN;

D O I：

10.2217/fmb-2016-0211

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

引用

页码：565 / 571

页数：7

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