Completely resected stage IIIA non-small cell lung cancer: The significance of primary tumor location and N2 station

被引:92
|
作者
Ichinose, Y
Kato, H
Koike, T
Tsuchiya, R
Fujisawa, T
Shimizu, N
Watanabe, Y
Mitsudomi, T
Yoshimura, M
Tsuboi, M
机构
[1] Kyushu Natl Canc Ctr, Dept Chest Surg, Minami Ku, Fukuoka 8111395, Japan
[2] Tokyo Med Univ, Tokyo, Japan
[3] Niigata Canc Ctr Hosp, Niigata, Japan
[4] Natl Canc Ctr Hosp, Tokyo, Japan
[5] Chiba Univ, Sch Med, Chiba 280, Japan
[6] Okayama Univ, Sch Med, Okayama 700, Japan
[7] Kanazawa Univ, Sch Med, Kanazawa, Ishikawa 920, Japan
[8] Aichi Canc Ctr Hosp, Aichi, Japan
来源
关键词
D O I
10.1067/mtc.2001.116473
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The number of N2 stations (single vs multiple N2 stations) is an important prognostic factor in patients with completely resected stage IIIA-N2 non-small cell lung cancer. However, the significance of both the N2 station(s) actually involved and the primary tumor location remains unclear. Methods: The database was built with the use of a questionnaire survey on the survival of patients with pathologic stage IIIA-N2 non-small cell lung cancer completely resected between January 1992 and December 1993. The survey was performed by the Japan Clinical Oncology Group as of July 1999. The data include information on the survival and N2 stations of 402 patients. Results: A, frequently metastasized single N2 station was the lower pretracheal station in primary tumors in the right upper lobe, the subaortic station in the left upper lobe, and the subcarinal station in the right middle or lower lobe and the left lower lobe. In multiple N2 stations, the frequency of metastasis of the N2 station observed in a single N2 station was as high as 72% to 89%, and one or two other frequently metastasized stations were added to each group. Regarding the survival of patients with a primary tumor in each lobe except for the left lower lobe, a single N2 station resulted in a significantly better survival than did multiple N2 stations. Furthermore, the overall survivals classified according to each primary site showed a significant difference among the four primary sites (P =.04). Conclusions: The primary tumors in each lobe showed a prevalence of N2 station(s). The number of N2 stations is a good prognosticator except in patients with a primary tumor in the left lower lobe. In addition, the site of a primary tumor itself is also considered to influence the survival of the patients.
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页码:803 / 808
页数:6
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