Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years

被引：6

作者：

Lima, Hildener Nogueira ^{[1
]}

Botosso, Viviane Fongaro ^{[2
]}

Leal Oliveira, Danielle Bruna ^{[1
]}

de Almeida Campos, Angelica Cristine ^{[1
]}

Leal, Andrea Lima ^{[1
]}

Silva, Tereza Souza ^{[1
]}

Ramos Bosso, Patricia Alves ^{[1
]}

Pedroso Moraes, Claudia Trigo ^{[2
]}

da Silva Filho, Claudionor Gomes ^{[1
]}

Vieira, Sandra Elisabete ^{[3
]}

Gilio, Alfredo Elias ^{[3
]}

Stewien, Klaus Eberhard ^{[1
]}

Durigon, Edison Luiz ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508900 Sao Paulo, Brazil

[2] Inst Butantan, BR-05503900 Sao Paulo, Brazil

[3] Univ Sao Paulo, Univ Hosp, BR-05508900 Sao Paulo, Brazil

来源：

VIRUS RESEARCH | 2012年 / 163卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

HRSV; Small hydrophobic protein; Molecular epidemiology; SUBGROUP-B; CIRCULATION PATTERNS; G-PROTEIN; GROUP-A; NOSOCOMIAL OUTBREAK; STRAINS; GLYCOPROTEIN; DUPLICATION; EVOLUTION; GENOTYPES;

D O I：

10.1016/j.virusres.2011.08.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples. We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB. It is also shown that the novel BA-like genotype was well segregated from the others, indicating that the mutations are not limited to the G gene. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：82 / 86

页数：5

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