Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathway

被引：49
|
作者：
You, Jing [1 ]
Shi, Xiaoyan [1 ]
Liang, Huimin [2 ]
Ye, Juan [1 ]
Wang, Lupeng [1 ]
Han, Huanxiao [1 ]
Fang, Hongyu [1 ]
Kang, Wenyi [1 ]
Wang, Tianxiao [1 ]
机构：
[1] Henan Univ, Coll Pharm, Kaifeng 475004, Henan, Peoples R China
[2] Henan Univ, Huaihe Hosp, Kaifeng 475000, Henan, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 39期
关键词：
cystathionine-gamma-lyase; H2S; transcription factor STAT3; breast cancer; growth; HYDROGEN-SULFIDE; COLON-CANCER; CELL-PROLIFERATION; PHOSPHORYLATION; TUMOR; TRANSCRIPTION; ANGIOGENESIS; INFLAMMATION; TRANSDUCER; EXPRESSION;
D O I：
10.18632/oncotarget.20057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Here we provide evidences to link cystathionine-gamma-lyase (CSE) to the development of breast cancer. CSE expression is up-regulated in both breast cancers and breast cancer cell lines and results in proliferation and migration of breast cancer cells. CSE Function in breast cancer depends on the STAT3 signaling pathway, a regulator of critical cell functions including cell growth in a wide variety of human cancer cells via activating the expression of relative genes. STAT3 positively relates to CSE expression. It activates the CSE promoter via a direct binding to the promoter. Moreover, CSE could reversely regulate STAT3 expression and consequently enhance the effect of STAT3 on CSE. Taken together, these data demonstrate for the first time the roles of CSE in breast cancer leading to breast cancer development in association with STAT3 signaling pathway.
引用
收藏
页码：65677 / 65686
页数：10
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