Should intravesical Bacillus Calmette-Guerin be employed in transplant recipients with bladder carcinoma?

被引：13
|
作者：
Sun, H. -Y. [1 ,2 ]
Singh, N. [1 ,3 ]
机构：
[1] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA
[2] Natl Taiwan Univ, Coll Med, Dept Internal Med, Natl Taiwan Univ Hosp, Taipei, Taiwan
[3] Univ Pittsburgh, Div Infect Dis, Pittsburgh, PA USA
来源：
TRANSPLANT INFECTIOUS DISEASE | 2010年 / 12卷 / 04期
关键词：
transplant; bladder carcinoma; pro-inflammatory; responses; Bacillus Calmette-Guerin; BCG; PHASE-III TRIAL; KIDNEY-TRANSPLANTATION; BCG IMMUNOTHERAPY; MYCOBACTERIUM-BOVIS; IN-SITU; IMMUNOSUPPRESSIVE DRUGS; EUROPEAN ORGANIZATION; IMMUNE-RESPONSES; CANCER INCIDENCE; MESSENGER-RNA;
D O I：
10.1111/j.1399-3062.2010.00506.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bacillus Calmette-Guerin (BCG) exerts its antitumor activity through induction of pro-inflammatory cytokines, while immunosuppressive agents prevent organ rejection by suppressing pro-inflammatory and promoting anti-inflammatory responses. Thus, in the setting of transplant populations, the use of intravesical BCG for bladder cancer has the possibility of either promoting allograft rejection or being rendered ineffective by the action of immunosuppressive agents that block pro-inflammatory responses. We discuss the potential immunologic interactions between BCG and immunosuppression, and review relevant outcomes in renal transplant recipients with bladder cancer receiving intravesical BCG.
引用
收藏
页码：358 / 362
页数：5
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