Interaction of naproxen with β-cyclodextrin and its derivatives/polymer: experimental and molecular modeling studies

被引：17
|
作者：
Banik, Abhijit [1 ]
Gogoi, Paramartha [2 ]
Saikia, Monali Dutta [1 ]
机构：
[1] Arya Vidyapeeth Coll, Dept Chem, Gauhati 781016, Assam, India
[2] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2012年 / 72卷 / 3-4期
关键词：
beta-Cyclodextrin; Inclusion complex; Formation constant; Naproxen; Stabilization energy; INCLUSION COMPLEXES; ALPHA-CYCLODEXTRIN; GAMMA-CYCLODEXTRIN; CAPILLARY-ELECTROPHORESIS; CALORIMETRIC TITRATION; AQUEOUS-SOLUTION; RECOGNITION; ADSORPTION; ENTROPY; BINDING;
D O I：
10.1007/s10847-011-0014-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interaction of naproxen with beta-cyclodextrin and its derivatives (hosts) as well as polymer has been studied using UV Visible (UV-Vis), Fourier Transform Infrared (FTIR), Nuclear Magnetic Resonance (NMR) spectroscopy and Scanning electron microscopy (SEM). In this paper, the solid inclusion complexes were prepared by freeze drying method. The formation constants of the complexes were determined by UV-Vis method. The adsorption properties of naproxen with beta-Cyclodextrin bonded silica stationary phase (CDS) were studied for an in-depth understanding of the host-guest interaction. The inclusion process involving naproxen and hosts was investigated by using the PM3 quantum-mechanical semiempirical method. The stabilization energy values obtained from the semiempirical calculation showed the same relation with the formation constant values determined by UV-Vis spectroscopy.
引用
收藏
页码：449 / 458
页数：10
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