Wavelength specific activation of PI 3-kinase by UVB irradiation

被引：25
|
作者：
Kabuyama, Y [1 ]
Hamaya, M [1 ]
Homma, Y [1 ]
机构：
[1] Fukushima Med Coll, Inst Biomed Sci, Dept Biomol Sci, Fukushima 9601295, Japan
来源：
FEBS LETTERS | 1998年 / 441卷 / 02期
关键词：
ultraviolet B; phosphatidylinositol; 3-kinase; cell death; tyrosine kinase; reactive oxygen intermediate;
D O I：
10.1016/S0014-5793(98)01565-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effect of UVB irradiation on phospholipid metabolism using normal human diploid skin fibroblasts, When cells were exposed to monochromatic UV Light, the intracellular PIP3 level was increased within 1 min in a wavelength-specific manner. The increase was most marked in the UVB range and was inhibited by a PI 3-kinase inhibitor, tyrosine kinase inhibitor, or antioxidant reagents. Furthermore, the decrease of cell viability induced by UVB irradiation was significantly blocked by wortmannin. These results suggest that PI 3-kinase activation is involved in novel cellular responses specific for UVB that lead to cell death. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：297 / 301
页数：5
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