One-Pot Efficient Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives from (N-Isocyanimino)triphenylphosphorane, Carboxylic Acids, and Aromatic Bis-Aldehydes

被引：29
|
作者：
Ramazani, Ali [1 ]
Ahmadi, Yavar [2 ]
Mahyari, Amir [1 ]
机构：
[1] Zanjan Univ, Dept Chem, Zanjan, Iran
[2] Islamic Azad Univ, Zanjan, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 15期
基金：
美国国家科学基金会;
关键词：
Aromatic carboxylic acid; aza-Wittig reaction; heteroaromatic carboxylic acid; (N-isocyanimino)triphenylphosphorane; 1; 3; 4-oxadiazole; STABILIZED PHOSPHORUS YLIDES; POLYMER-SUPPORTED REAGENTS; SINGLE-CRYSTAL STRUCTURE; N-VINYLIC PHOSPHAZENES; AZA-WITTIG REACTION; X-RAY-STRUCTURE; STEREOSELECTIVE-SYNTHESIS; 3-COMPONENT REACTION; SILICA-GEL; ACETYLENIC ESTERS;
D O I：
10.1080/00397911.2010.501480
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[image omitted] Reactions of (N-isocyanimino)triphenylphosphorane with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in good yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.
引用
收藏
页码：2273 / 2282
页数：10
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