Transmissibility of livestock-associated methicillin-resistant Staphylococcus aureus (ST398) in Dutch hospitals

被引:86
|
作者
Wassenberg, M. W. M. [1 ,2 ]
Bootsma, M. C. J. [3 ,4 ]
Troelstra, A. [2 ]
Kluytmans, J. A. J. W. [5 ,6 ]
Bonten, M. J. M. [2 ,3 ]
机构
[1] Univ Med Ctr Utrecht, Dept Internal Med & Infect Dis, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[4] Univ Utrecht, Dept Math, Fac Sci, Utrecht, Netherlands
[5] Amphia Hosp, Lab Microbiol & Infect Control, Breda, Netherlands
[6] Vrije Univ Amsterdam Med Ctr, Dept Med Microbiol & Infect Control, Amsterdam, Netherlands
关键词
Livestock-associated MRSA; methicillin-resistant Staphylococcus aureus; nosocomial transmission; ST398;
D O I
10.1111/j.1469-0691.2010.03260.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
P>We quantified nosocomial transmission rates of sequence type (ST) 398 methicillin-resistant Staphylococcus aureus (MRSA) (an emerging livestock-associated MRSA clone) and non-ST398 MRSA isolates in patients hospitalized without infection control measures in 51 Dutch hospitals. Identification of 174 index patients initiated 139 post-exposure screenings of 9925 persons. There were 65 genotype-confirmed secondary cases (three and 62 for ST398 and non-ST398 MRSA, respectively), yielding a relative transmission risk for ST398 MRSA of 0.28 (95% CI 0.09-0.90), which was not sensitive to adjustment for duration of hospitalization at time of detection. Nosocomial transmission of ST398 MRSA is 72% less likely than that of non-ST398 MRSA strains.
引用
收藏
页码:316 / 319
页数:4
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