Synthesis of Inherently Chiral Azacalix[4]arenes and Diazadioxacalix[4]arenes

被引：43
|
作者：
Katz, Jeffrey L. [1 ]
Tschaen, Brittany A. [1 ]
机构：
[1] Colby Coll, Dept Chem, Waterville, ME 04901 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 19期
基金：
美国国家科学基金会;
关键词：
CRYSTAL-STRUCTURE; CAVITY; OXACALIXARENES; COMPLEXATION;
D O I：
10.1021/ol1017454
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described are nucleophilic aromatic substitution reactions for the synthesis of inherently chiral azacalix[4]arenes and diazadioxacalix[4]arenes comprised of two or three different aromatic monomers. A variety of functional groups are tolerated at the 2-, 4-, and 5-positions on the nucleophilic-component monomers; reactions are run under ambient atmosphere; and the macrocycles are constructed without isolation of intermediate linear species.
引用
收藏
页码：4300 / 4303
页数：4
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