Is Age-Related Macular Degeneration a Microvascular Disease?

被引：24

作者：

Mullins, Robert F. ^{[1
]}

Khanna, Aditi ^{[1
]}

Schoo, Desi P. ^{[1
]}

Tucker, Budd A. ^{[1
]}

Sohn, Elliott H. ^{[1
]}

Drack, Arlene V. ^{[1
]}

Stone, Edwin M. ^{[1
]}

机构：

[1] Univ Iowa, Dept Ophthalmol & Visual Sci, Lowa City, IA 52242 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

Age-related macular degeneration; Choriocapillaris; Choroid; Complement; RPE; COMPLEMENT FACTOR-H; QUALITY-OF-LIFE; HUMAN EYES; CHORIOCAPILLARIS; ACTIVATION; DRUSEN; RISK; COMPONENTS; DEPOSITS;

D O I：

10.1007/978-1-4614-3209-8_36

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Age-related macular degeneration (AMD) is a common, degenerative disease of the central retina affecting millions of elderly in the USA alone and many more worldwide. A better understanding of the pathophysiology of AMD will be essential for developing new treatments. In this review, we discuss the potential impact of complement complex deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris loss and drusen formation. We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies.

引用

页码：283 / 289

页数：7

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