Successful Curative Therapy With Rituximab and Allogeneic Haematopoietic Stem Cell Transplantation for MALT Lymphoma Associated With STK4-Mutated CD4+Lymphocytopenia

被引：13
|
作者：
Lum, Su Han [1 ]
Bonney, Denise [1 ]
Cheesman, Edmund [2 ]
Wrignt, Neville B. [3 ]
Hughes, Stephen [4 ]
Wynn, Robert [1 ]
机构：
[1] Royal Manchester Childrens Hosp, Dept Blood & Marrow Transplant, Oxford Rd, Manchester M13 9WL, Lancs, England
[2] Royal Manchester Childrens Hosp, Diagnost Paediat Histopathol Serv, Manchester, Lancs, England
[3] Royal Manchester Childrens Hosp, Dept Radiol, Manchester, Lancs, England
[4] Royal Manchester Childrens Hosp, Dept Paediat Allergy & Immunol, Manchester, Lancs, England
来源：
PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 09期
关键词：
CD4+lymphocytopenia; haematopoietic stem cell transplantation; MALT lymphoma; rituximab; LYMPHOCYTOPENIA;
D O I：
10.1002/pbc.26048
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Idiopathic CD4+ lymphocytopenia and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are rare diseases in children. We report the first case of a child with STK4-mutated CD4+ lymphocytopenia who developed Epstein-Barr virus associated MALT lymphoma arising in the salivary gland. The child achieved complete remission with rituximab, and her immunodeficiency was cured by haematopoietic stem cell transplantation. The child remained well 24 months post transplantation. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：1657 / 1659
页数：3
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