Successful Curative Therapy With Rituximab and Allogeneic Haematopoietic Stem Cell Transplantation for MALT Lymphoma Associated With STK4-Mutated CD4+Lymphocytopenia

被引：13
|
作者：
Lum, Su Han [1 ]
Bonney, Denise [1 ]
Cheesman, Edmund [2 ]
Wrignt, Neville B. [3 ]
Hughes, Stephen [4 ]
Wynn, Robert [1 ]
机构：
[1] Royal Manchester Childrens Hosp, Dept Blood & Marrow Transplant, Oxford Rd, Manchester M13 9WL, Lancs, England
[2] Royal Manchester Childrens Hosp, Diagnost Paediat Histopathol Serv, Manchester, Lancs, England
[3] Royal Manchester Childrens Hosp, Dept Radiol, Manchester, Lancs, England
[4] Royal Manchester Childrens Hosp, Dept Paediat Allergy & Immunol, Manchester, Lancs, England
来源：
PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 09期
关键词：
CD4+lymphocytopenia; haematopoietic stem cell transplantation; MALT lymphoma; rituximab; LYMPHOCYTOPENIA;
D O I：
10.1002/pbc.26048
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Idiopathic CD4+ lymphocytopenia and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are rare diseases in children. We report the first case of a child with STK4-mutated CD4+ lymphocytopenia who developed Epstein-Barr virus associated MALT lymphoma arising in the salivary gland. The child achieved complete remission with rituximab, and her immunodeficiency was cured by haematopoietic stem cell transplantation. The child remained well 24 months post transplantation. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：1657 / 1659
页数：3
相关论文
共 31 条
  • [1] Successful curative therapy with Rituximab and haemotopoietic stem cell transplant in a child with idiopathic CD4+lymphocytopenia and EBV-driven MALT lymphoma
    Lum, S. H.
    Hughes, S.
    Bonney, D.
    Cheesman, E.
    Wynn, R.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S466 - S467
  • [2] Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+lymphocytopenia
    Cervera, Carlos
    Fernandez-Aviles, Francesc
    de la Calle-Martin, Oscar
    Bosch, Xavier
    Rovira, Montserrat
    Plana, Montse
    Moreno, Asuncion
    Garcia, Felipe
    Miro, Jose M.
    Martinez, Antonio
    Gallart, Teresa
    Carreras, Enric
    Blade, Joan
    Gatell, Jose M.
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2011, 87 (01) : 87 - 91
  • [3] Successful fludarabine-based hematopoietic stem cell transplantation in a pediatric patient with idiopathic CD4+ lymphocytopenia
    Hamidieh, Amir Ali
    Pourpak, Zahra
    Hamdi, Amir
    Nabavi, Mohammad
    Ghavamzadeh, Ardeshir
    PEDIATRIC TRANSPLANTATION, 2013, 17 (04) : E109 - E111
  • [4] Adoptive immunotherapy with CD4+donor lymphocyte transfusion after allogeneic haematopoietic stem cell transplantation
    Wiesneth, M
    Stefanic, M
    von Harsdorf, S
    Bischof, C
    Erne, E
    Krug, E
    Maccari, B
    Bunjes, D
    HIGH-DOSE THERAPY AND TRANSPLANTATION OF HAEMATOPOIETIC STEM CELLS, 2000, : 165 - 169
  • [5] Intracellular ATP production in CD4+T cells as an immune cell function assay after allogeneic haematopoietic stem cell transplantation
    Waterhouse, M.
    Konukiewitz, L.
    Bertz, H.
    Finke, J.
    BONE MARROW TRANSPLANTATION, 2013, 48 : S147 - S147
  • [6] Quantification of the HCMV-specific CD4+ and CD8+ T-cell immune response in children receiving allogeneic haematopoietic stem cell transplantation
    Locatelli, F
    Lilleri, D
    Lozza, L
    Giorgiani, G
    De Stefano, P
    Fornara, C
    Telli, S
    Maccario, R
    Revello, MG
    Gerna, G
    BONE MARROW TRANSPLANTATION, 2005, 35 : S26 - S27
  • [7] The impact of graft composition on early CD4+T-cell recovery and clinical outcome of patients who underwent allogeneic haematopoietic stem cell transplantation
    Fedele, R.
    Martino, M.
    Moscato, T.
    Messina, G.
    Console, G.
    Irrera, G.
    Cuzzola, M.
    Spiniello, E.
    Garreffa, C.
    Dattola, A.
    Callea, I.
    Iacopino, O.
    Pontari, A.
    Iacopino, P.
    BONE MARROW TRANSPLANTATION, 2010, 45 : S201 - S201
  • [8] Restoration and maintenance of naive CD31+and CD31-CD45RA+RO-CD4+T-cell compartments after paediatric allogeneic haematopoietic stem cell transplantation
    Guengoer, T.
    Rufibach, K.
    Dougoud, S.
    Hauri-Hohl, M.
    Oberholzer-Koechli, S.
    BONE MARROW TRANSPLANTATION, 2011, 46 : S35 - S35
  • [9] The reconstitution of CD45RBhiCD4+ naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation
    Hirayama, M
    Azuma, E
    Jiang, Q
    Kobayashi, M
    Iwamoto, S
    Kumamoto, T
    Kisenge, R
    Yamamoto, H
    Komada, Y
    BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (02) : 700 - 707
  • [10] Low numbers of regulatory T-cells (% CD4 T-cells) within the haematopoietic stem scll graft are associated with poor engraftment and worse overall survival following allogeneic haematopoietic stem cell transplantation
    Danby, R.
    Nair, S.
    Medd, P.
    Ellis, M.
    Zhang, W.
    Peniket, A.
    Roberts, D.
    BONE MARROW TRANSPLANTATION, 2012, 47 : S305 - S305
1234