Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

被引：1

作者：

Santos, Andreia Fuentes ^{[1
]}

Queiroz Souza, Marilia Moraes ^{[2
]}

Pauli, Karoline Bach ^{[3
]}

da Silva, Gustavo Ratti ^{[1
]}

Marques, Midia Wolff ^{[4
]}

Auth, Pablo Alvarez ^{[1
]}

Bortolucci, Wanessa de Campos ^{[5
]}

Gazim, Zilda Cristiani ^{[5
]}

Linde, Giani Andrea ^{[6
]}

Colauto, Nelson Barros ^{[6
]}

Wietzikoski Lovato, Evellyn Claudia ^{[2
]}

dos Reis Livero, Francislaine Aparecida ^{[7
]}

机构：

[1] Univ Paranaense, Grad Program Anim Sci Emphasis Bioact Prod, Umuarama, Brazil

[2] Univ Paranaense, Grad Program Med Plants & Phytotherapeut Basic At, Umuarama, Brazil

[3] Fed Univ Integracao Latinoamer, Foz Do Iguacu, Brazil

[4] Univ Paranaense, Specializat Trauma Orthoped & Sports Physiotherap, Umuarama, Parana, Brazil

[5] Univ Paranaense, Grad Anim Sci Emphasis Bioact Prod, Grad Program Biotechnol Appl Agr, Umuarama, Brazil

[6] Univ Fed Bahia, Salvador, BA, Brazil

[7] Univ Paranaense, Grad Program Med Plants & Phytotherapeut Basic At, Grad Anim Sci Emphasis Bioact Prod, Grad Program Biotechnol Appl Agr, Umuarama, Brazil

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2022年 / 21卷 / 02期

关键词：

Alzheimer; Bacopa monnieri; Epilepsy; Parkinson; Schizophrenia; PHENCYCLIDINE RAT MODEL; DECREASED GABA RECEPTOR; INDUCED EPILEPTIC RATS; NEUROPROTECTIVE ROLE; OBJECT RECOGNITION; PARKINSONS-DISEASE; COGNITIVE DEFICITS; PREFRONTAL CORTEX; DOUBLE-BLIND; BACOSIDE-A;

D O I：

10.37360/blacpma.22.21.2.09

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Bacopa monnieri (L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and activity of B. monnieri in the central nervous system. It reviewed articles on B. monnieri using Google Scholar, SciELO, Science Direct, Lilacs, Medline, and PubMed. Saponins are the main compounds in extracts of B. monnieri. Pharmacological studies showed that B. monnieri improves learning and memory and presents biological effects against Alzheimer's disease, Parkinson's disease, epilepsy, and schizophrenia. No preclinical acute toxicity was reported. However, gastrointestinal side effects were reported in some healthy elderly individuals. Most studies with B. monnieri have been preclinical evaluations of cellular mechanisms in the central nervous system and further translational clinical research needs to be performed to evaluate the safety and efficacy of the plant.

引用

页码：131 / 155

页数：25

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