Methylenetetrahydrofolate reductase C677T polymorphism is not associated with male infertility in a South Indian population

被引：22
|
作者：
Vani, G. T. [1 ,2 ]
Mukesh, N. [1 ,2 ]
Devi, P. Rama [3 ]
Rani, P. Usha [1 ,2 ,4 ]
Reddy, P. P. [1 ,2 ,4 ]
机构：
[1] Osmania Univ, Inst Genet, Hyderabad 500073, Andhra Pradesh, India
[2] Osmania Univ, Hosp Genet Dis, Hyderabad 500073, Andhra Pradesh, India
[3] Mahatma Gandhi Natl Inst Res & Social Act, Ramas Inst Fertil, Hyderabad, Andhra Pradesh, India
[4] Mahatma Gandhi Natl Inst Res & Social Act, Sch Human Genome Res & Genet Disorders, Hyderabad, Andhra Pradesh, India
来源：
ANDROLOGIA | 2012年 / 44卷
关键词：
C677T polymorphism; idiopathic infertility; male infertility; methylenetetrahydrofolate reductase; nonobstructive azoospermia; oligoasthenoteratozoospermia; METHIONINE SYNTHASE GENE; MALE FACTOR SUBFERTILITY; MATERNAL RISK-FACTORS; DNA METHYLATION; FOLATE METABOLISM; HYDROGEN-PEROXIDE; HUMAN SPERMATOZOA; COMMON MUTATION; SEMEN QUALITY; ZINC-SULFATE;
D O I：
10.1111/j.1439-0272.2011.01172.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Previous studies have revealed that genetic factors may be involved in regulating the mechanism of infertility, e.g., MTHFR gene polymorphism in the development of male infertility. The aim of this study is to examine whether an association exists between MTHFR C677T polymorphism and male infertility. The study was carried out by means of a PCR-RFLP assay in 206 infertile men and 230 ethnically matched controls. The statistical analysis using two-sided Fishers exact test and Pearson chi-squared test showed CT genotype is associated nonsignificantly with male infertility (OR = 1.19, 95% CI = 0.711.97). Because of the lack of TT homozygotes in the controls, a combined odds ratio of CT and TT homozygotes against the control has been calculated (OR = 1.36, 95% CI = 0.832.22), and the same was insignificant. The overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility.
引用
收藏
页码：252 / 259
页数：8
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