Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia

被引：41
|
作者：
Lambropoulos, AF [1 ]
Agorastos, T
Foka, ZJ
Chrisafi, S
Constantinidis, TC
Bontis, J
Kotsis, A
机构：
[1] Aristotle Univ Thessaloniki, Fac Med, Dept Biol & Genet, GR-54124 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Fac Med, Hippokrat Hosp Thessaloniki, Clin Obstet & Gynecol, GR-54124 Thessaloniki, Greece
[3] Democritus Univ Thrace, Fac Med, Hyg Lab, Komotini, Greece
来源：
CANCER LETTERS | 2003年 / 191卷 / 02期
关键词：
methylenetetrahydrofolate reductase; MTHFR C677T polymorphism; cervical neoplasia; cervical cancer;
D O I：
10.1016/S0304-3835(02)00675-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of the study was to explore a possible association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cervical neoplasia. A total of 229 women were subjected to cytologic and colposcopic evaluation. Ninety-one of them were found to be normal, and served as the control group, while the other 138 of them had present or past histologically proven cervical pathology (patients group). All patients and controls were investigated for the MTHFR C677T polymorphism. Statistical analysis between the groups of cases with cervical intraepithelial neoplasia or invasive cervical cancer and the control group did not reveal any statistically significant difference in the frequency of the MTHFR C677T polymorphism. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：187 / 191
页数：5
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