A historical review of XDR tuberculosis in the Western Cape province of South Africa

被引：0

作者：

Symons, Gregory ^{[2
,4
]}

Shean, Karen ^{[2
,4
]}

Pietersen, Elize ^{[2
,4
]}

Smit, Richard van Zyl ^{[2
,4
]}

Pool, Lititia ^{[2
,4
]}

Davids, Malika ^{[2
,4
]}

Wilcox, Paul ^{[2
,4
]}

Dheda, Keertan ^{[1
,3
]}

机构：

[1] Univ Cape Town, Lung Infect & Immun Unit, UCT Lung Inst, ZA-7700 Rondebosch, South Africa

[2] Univ Cape Town, Dept Med, UCT Lung Inst, ZA-7700 Rondebosch, South Africa

[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa

[4] Univ Cape Town, Lung Infect & Immun Unit, Div Pulmonol, ZA-7700 Rondebosch, South Africa

来源：

SAMJ SOUTH AFRICAN MEDICAL JOURNAL | 2011年 / 101卷 / 09期

关键词：

MULTIDRUG-RESISTANT TUBERCULOSIS; DRUGS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.

引用

页码：636 / +

页数：2

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