Unusual C25 steroids produced by a sponge-derived Penicillium citrinum

被引：92

作者：

Amagata, T ^{[1
]}

Amagata, A

Tenney, K

Valeriote, FA

Lobkovsky, E

Clardy, J

Crews, P

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

[3] Josephine Ford Canc Ctr, Detroit, MI 48202 USA

[4] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[5] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0356800

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structurally unique steroids, isocyclocitrinol A (1) and 22-acetylisocyclocitrinol A (2), were isolated from the extract of a saltwater culture of sponge-derived Penicilliun citrinum. The structures were established by analysis of 1D and 2D NMR data. The absolute structures were determined on the basis of X-ray structure analysis and application of modified Mosher's method. Furthermore, the structure of cyclocitrinol (3a) previously isolated from a terrestrial P. citrinum was revised as 3b. Compounds 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.

引用

页码：4393 / 4396

页数：4

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