Orally active non-peptide inhibitors of human renin

被引:0
|
作者
Barrett, D
Langston, S
机构
[1] Fujisawa Pharmaceut Co Ltd, Med Chem Res Labs, Yodogawa Ku, Osaka 5328514, Japan
[2] Millennium Pharmaceut, Merrifield Ctr, Cambridge CB1 3LQ, England
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:52 / 52
页数:1
相关论文
共 50 条
  • [21] Therapeutic potential of non-peptide chymase inhibitors
    Doggrell, Sheila A.
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2008, 18 (05) : 485 - 499
  • [22] SR146131:: A new, potent, non-peptide orally active CCKA receptor agonist.
    Bignon, E
    Boigegrain, R
    Cottineau, M
    Petereau, C
    Rockstroh, MP
    Seban, E
    Servant, O
    Pascal, M
    Maffrand, JP
    Le Fur, G
    GASTROENTEROLOGY, 1998, 114 (04) : A1129 - A1129
  • [23] Effect of YM471, an orally active non-peptide arginine vasopressin receptor antagonist, on human vascular smooth muscle cells
    Tahara, A
    Tsukada, J
    Tomura, Y
    Kusayama, T
    Wada, K
    Ishii, N
    Yatsu, T
    Uchida, W
    Taniguchi, N
    Tanaka, A
    JOURNAL OF HYPERTENSION, 2002, 20 (09) : 1807 - 1814
  • [24] Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors
    McKittrick, Brian A.
    Caldwell, John P.
    Bara, Thomas
    Boykow, George
    Chintala, Madhu
    Clader, John
    Czarniecki, Michael
    Courneya, Brandy
    Duffy, Ruth
    Fleming, Linda
    Giessert, Rachel
    Greenlee, William J.
    Heap, Charles
    Hong, Liwu
    Huang, Ying
    Iserloh, Ulrich
    Josien, Hubert
    Khan, Tanweer
    Korfmacher, Walter
    Liang, Xian
    Mazzola, Robert
    Mitra, Soumya
    Moore, Kristina
    Orth, Peter
    Rajagopalan, Murali
    Roy, Sudipta
    Sakwa, Samuel
    Strickland, Corey
    Vaccaro, Henry
    Voigt, Johannes
    Wang, Hongwu
    Wong, Jesse
    Zhang, Rumin
    Zych, Andrew
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (07) : 1592 - 1596
  • [25] New class of potent, nonpeptidic, orally active renin inhibitors
    Remen, Lubos
    Bezencon, Olivier
    Boss, Christoph
    Bur, Daniel
    Corminboeuf, Olivier
    Grisostomi, Corinna
    Richard-Bildstein, Sylvia
    Sifferlen, Thierry
    Weller, Thomas
    Binkert, Christoph
    Fischli, Walter
    Hess, Patrick
    Prade, Lars
    Steiner, Beat
    Strickner, Panja
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
  • [26] Design and syntheses of non-peptide γ-secretase inhibitors.
    Adejare, A
    Wells, RM
    Golde, TE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U965 - U965
  • [27] Pharmacological characterization of linzagolix, a novel, orally active, non-peptide antagonist of gonadotropin-releasing hormone receptors
    Tezuka, Motohiro
    Tamai, Yasuaki
    Kuramochi, Yu
    Kobayashi, Kaoru
    Fushimi, Nobuhiko
    Kiguchi, Sumiyoshi
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2022, 49 (10) : 1082 - 1093
  • [28] Novel renin inhibitors containing a non-peptide aminoalkanoyl moiety at P1-P1′ position
    Winiecka, I.
    Marszalek, D.
    Goldnik, A.
    Jaworski, P.
    Mazurek, A. P.
    PHARMAZIE, 2014, 69 (04): : 263 - 270
  • [29] Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines
    Tucci, FC
    White, NS
    Markison, S
    Joppa, M
    Tran, JA
    Fleck, BA
    Madan, A
    Dyck, BP
    Parker, J
    Pontillo, J
    Arellano, LM
    Marinkovic, D
    Jiang, WL
    Chen, CW
    Gogas, KR
    Goodfellow, VS
    Saunders, J
    Fosters, AC
    Chen, C
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (19) : 4389 - 4395
  • [30] Piperidines as potent, orally active renin inhibitors: Optimization of the amide substituent
    Remen, Lubos
    Bezencon, Olivier
    Bur, Daniel
    Weller, Thomas
    Richard-Bildstein, Sylvia
    Sifferlen, Thierry
    Corminboeuf, Olivier
    Grisostomi, Corinna
    Boss, Christoph
    Prade, Lars
    Delahaye, Stephane
    Treiber, Alexander
    Strickner, Panja
    Binkert, Christoph
    Hess, Patrick
    Steiner, Beat
    Fischli, Walter
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239