Structural Characteristics and Anticancer Activity In Vitro of Fucoidans from Brown Seaweeds Sargassum miyabei and S. oligocystum

被引：9

作者：

Surits, V. V. ^{[1
]}

Usoltseva, R. V. ^{[1
]}

Shevchenko, N. M. ^{[1
]}

Thinh, P. D. ^{[2
]}

Ermakova, S. P. ^{[1
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, 159 Prosp 100 Let Vladivostoku, Vladivostok 690022, Russia

[2] Vietnam Acad Sci & Technol, Nhatrang Inst Technol Res & Applicat, 02 Hung Vuong St, Nha Trang, Vietnam

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 01期

关键词：

brown seaweeds; Sargassum; fucoidan; anticancer activity; POLYSACCHARIDES; ALGAE; ANTITUMOR;

D O I：

10.1007/s10600-020-02938-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High-purity fucoidan fractions were obtained from brown seaweeds Sargassum miyabei and S. oligocystum. Both first fractions were mannnogalactofucans; second, galactofucans. Fucoidans from S. miyabei contained acetyls. The isolated polysaccharides were not cytotoxic at concentrations up to 400 mu g/mL. Formation and growth of colonies of HT-29 and HCT-116 cells were weakly inhibited by the tested fucoidans. Fucoidans SmiF2, SoF1, and SoF2 had the greatest anticancer effects against the DLD-1 cell line.

引用

页码：34 / 38

页数：5

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