Structural Characteristics and Anticancer Activity In Vitro of Fucoidans from Brown Seaweeds Sargassum miyabei and S. oligocystum

被引：9
|
作者：
Surits, V. V. [1 ]
Usoltseva, R. V. [1 ]
Shevchenko, N. M. [1 ]
Thinh, P. D. [2 ]
Ermakova, S. P. [1 ]
机构：
[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, 159 Prosp 100 Let Vladivostoku, Vladivostok 690022, Russia
[2] Vietnam Acad Sci & Technol, Nhatrang Inst Technol Res & Applicat, 02 Hung Vuong St, Nha Trang, Vietnam
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 01期
关键词：
brown seaweeds; Sargassum; fucoidan; anticancer activity; POLYSACCHARIDES; ALGAE; ANTITUMOR;
D O I：
10.1007/s10600-020-02938-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
High-purity fucoidan fractions were obtained from brown seaweeds Sargassum miyabei and S. oligocystum. Both first fractions were mannnogalactofucans; second, galactofucans. Fucoidans from S. miyabei contained acetyls. The isolated polysaccharides were not cytotoxic at concentrations up to 400 mu g/mL. Formation and growth of colonies of HT-29 and HCT-116 cells were weakly inhibited by the tested fucoidans. Fucoidans SmiF2, SoF1, and SoF2 had the greatest anticancer effects against the DLD-1 cell line.
引用
收藏
页码：34 / 38
页数：5
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