What lessons can be learned from studying the folding of homologous proteins?

被引：42

作者：

Nickson, Adrian A. ^{[1
]}

Clarke, Jane ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, MRC Ctr Prot Engn, Cambridge CB2 1EW, England

来源：

METHODS | 2010年 / 52卷 / 01期

基金：

英国惠康基金;

关键词：

Protein folding; Phi-Value; Protein families; Homologous proteins; PHI-VALUE ANALYSIS; SECONDARY STRUCTURE ELEMENTS; INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; GLOBAL ANALYSIS HIGHLIGHTS; TRANSITION-STATE STRUCTURE; BETA-SHEET PROTEIN; THERMUS-THERMOPHILUS; ALPHA-LACTALBUMIN; ENERGY LANDSCAPE; SH3; DOMAIN;

D O I：

10.1016/j.ymeth.2010.06.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：38 / 50

页数：13

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