miR-205-5p Mediated Downregulation of PTEN Contributes to Cisplatin Resistance in C13K Human Ovarian Cancer Cells

被引：39
|
作者：
Shi, Xiaoyan [1 ,3 ]
Xiao, Lan [4 ]
Mao, Xiaolu [5 ]
He, Jinrong [1 ,3 ]
Ding, Yu [1 ,3 ]
Huang, Jin [1 ,3 ]
Peng, Caixia [1 ,3 ]
Xu, Zihui [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Endocnnol & Metab, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Cent Lab, Wuhan, Hubei, Peoples R China
[4] An Hui Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Hefei, Anhui, Peoples R China
[5] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongii Med Coll, Dept Clin Lab, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN GENETICS | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
miR-205-5p; PTEN; cisplatin resistance; ovarian cancer; AKT; PANCREATIC-CANCER; INDUCED APOPTOSIS; TARGETING PTEN; LUNG-CANCER; INHIBITION; EXPRESSION; CARCINOMA; PATHWAY; LEADS;
D O I：
10.3389/fgene.2018.00555
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Cisplatin resistance is a major cause of treatment failure in advanced ovarian cancer. The limited evidence shows the paradoxical regulation of miR-205 on chemotherapy resistance in cancer. Herein, we found that miR-205-5p was enormously increased in cisplatin-resistant C13K ovarian cancer cells compared with its cisplatin-sensitive OV2008 parental cells using miRNA microarrays, which was further verified by quantitative PCR. Furthermore, we confirmed that inhibition of miR-205-5p upregulated PTEN and subsequently attenuated its downstream target p-AKT, which inversed C13K cells from cisplatin resistance to sensitivity. Our data suggest that miR-205-5p contributes to cisplatin resistance in C13K ovarian cancer cells may via targeting PTEN/AKT pathway.
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页数：8
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