Fabrication of substituted hydroxyapatite-starch-clay bio-composite coated titanium implant for new bone formation

被引：22

作者：

Prabakaran, Selvakani ^{[1
]}

Rajan, Mariappan ^{[1
]}

Geng, Zhaoli ^{[2
]}

Liu, Yi ^{[2
,3
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Nat Prod Chem, Biomat Med Chem Lab, Madurai 625021, Tamil Nadu, India

[2] Shandong Univ, Shandong Key Lab Oral Tissue Regenerat, Shandong Engn Lab Dent Mat & Oral Tissue Regenera, Dept Orthodont,Sch & Hosp Stomatol,Cheeloo Coll M, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2021年 / 271卷

基金：

中国国家自然科学基金;

关键词：

Clay-polymeric matrix; Electrophoretic deposition; mineral substituted hydroxyapatite; Tissue engineering; Wollastonite; MECHANICAL-PROPERTIES; WOLLASTONITE; SCAFFOLDS;

D O I：

10.1016/j.carbpol.2021.118432

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The clay/polymeric matrices have much attention from researchers in bio-medical applications due to their numerous uses. This study introduces new orthopedic titanium (Ti) implant with increasing bio-activity by treating the surface of the Ti implant with bio-compatible composite coating. Wollastonite (WST) clay combined minerals (Mg2+and Gd3+) substituted hydroxyapatite (HAP)/Starch composite was prepared using in-situ coprecipitation method. It was successfully coated on the orthopedic grade Ti plate by the Electrophoretic Deposition (EPD) method. The functionality, phase, morphology, and bio-activity analysis of the composite were evaluated by FT-IR, XRD, HR-TEM, and SEM analysis, respectively. The mechanical property, i.e., Vickers microhardness value of the MHAP/Starch/WST composite coated Ti plate, showed 242 +/- 1.92 Hv. The in-vitro MG-63 osteoblast cells viability, differentiation, and Ca mineralization of MHAP/Starch/WST composite suggests that this new implant will be used for bone regeneration application after careful evaluation of in-vivo and clinical studies.

引用

页数：11