Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement

被引：26
|
作者：
Kim, Kyunghee [1 ,2 ,3 ]
Lee, Jeongeun [1 ,2 ,3 ]
Moon, Bo Mi [4 ]
Seo, Ye Been [4 ]
Park, Chan Hum [4 ]
Park, Min [1 ,2 ,3 ]
Sung, Gun Yong [1 ,2 ,3 ]
机构：
[1] Hallym Univ, Cooperat Course Nanomed Device Engn, Chunchon 24252, South Korea
[2] Hallym Univ, Dept Mat Sci & Engn, Chunchon 24252, South Korea
[3] Hallym Univ, Integrat Mat Res Inst, Chunchon 24252, South Korea
[4] Hallym Univ, Coll Med, Nanobio Regenerat Med Inst, Chunchon 24252, South Korea
来源：
SENSORS | 2018年 / 18卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
urea biosensor; silk fibroin; amination; flow conditions; real-time monitoring; AMPEROMETRIC AMMONIUM ION; DIALYSIS THERAPY; ELECTRODE; CARBON; POLYANILINE; ACID; SENSOR; KOREA;
D O I：
10.3390/s18082607
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, a portable urea sensor that monitors the urea concentration in flow conditions was fabricated. We propose an electrochemical sensor that continually measures the urea concentration of samples flowing through it at a constant flow rate in real time. For the electrochemical sensing, a porous silk fibroin membrane with immobilized urease was mounted in a polydimethylsiloxane (PDMS) sensor housing. The fabricated urea sensor elicited linear current-concentration characteristics in the clinically significant concentration range (0.1-20 mM) based on peritoneal dialysis. The sensor maintained the linear current-concentration characteristics during operation in flow conditions.
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收藏
页数：11
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