Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement

被引：26

作者：

Kim, Kyunghee ^{[1
,2
,3
]}

Lee, Jeongeun ^{[1
,2
,3
]}

Moon, Bo Mi ^{[4
]}

Seo, Ye Been ^{[4
]}

Park, Chan Hum ^{[4
]}

Park, Min ^{[1
,2
,3
]}

Sung, Gun Yong ^{[1
,2
,3
]}

机构：

[1] Hallym Univ, Cooperat Course Nanomed Device Engn, Chunchon 24252, South Korea

[2] Hallym Univ, Dept Mat Sci & Engn, Chunchon 24252, South Korea

[3] Hallym Univ, Integrat Mat Res Inst, Chunchon 24252, South Korea

[4] Hallym Univ, Coll Med, Nanobio Regenerat Med Inst, Chunchon 24252, South Korea

来源：

SENSORS | 2018年 / 18卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

urea biosensor; silk fibroin; amination; flow conditions; real-time monitoring; AMPEROMETRIC AMMONIUM ION; DIALYSIS THERAPY; ELECTRODE; CARBON; POLYANILINE; ACID; SENSOR; KOREA;

D O I：

10.3390/s18082607

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, a portable urea sensor that monitors the urea concentration in flow conditions was fabricated. We propose an electrochemical sensor that continually measures the urea concentration of samples flowing through it at a constant flow rate in real time. For the electrochemical sensing, a porous silk fibroin membrane with immobilized urease was mounted in a polydimethylsiloxane (PDMS) sensor housing. The fabricated urea sensor elicited linear current-concentration characteristics in the clinically significant concentration range (0.1-20 mM) based on peritoneal dialysis. The sensor maintained the linear current-concentration characteristics during operation in flow conditions.

引用

页数：11

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