Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study

被引:31
|
作者
Poon, Anna K. [1 ,9 ]
Meyer, Michelle L. [2 ]
Tanaka, Hirofumi [3 ]
Selvin, Elizabeth [4 ]
Pankow, James [5 ]
Zeng, Donglin [6 ]
Loehr, Laura [1 ]
Knowles, Joshua W. [7 ,8 ]
Rosamond, Wayne [1 ]
Heiss, Gerardo [1 ]
机构
[1] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Sch Med, Dept Emergency Med, Chapel Hill, NC 27515 USA
[3] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[5] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA
[6] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Chapel Hill, NC 27515 USA
[7] Stanford Univ, Dept Med, Stanford, CA 94305 USA
[8] Stanford Univ, Cardiovasc Inst, Stanford, CA 94305 USA
[9] 1620 Tremont St,OBC 3-34, Boston, MA 02120 USA
基金
美国国家卫生研究院;
关键词
Insulin resistance; Homeostatic model assessment of insulin resistance; Triglyceride to high-density lipoprotein cholesterol ratio; Triglyceride and glucose index; Arterial stiffness; Aortic stiffness; Carotid-femoral pulse wave velocity; TRIGLYCERIDE GLUCOSE INDEX; CORONARY-HEART-DISEASE; ARTERIAL STIFFNESS; TOTAL CHOLESTEROL; CLAMP TECHNIQUE; HDL-C; SENSITIVITY; POPULATION; SECRETION; IMPACT;
D O I
10.1186/s12933-020-0986-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Insulin resistance may contribute to aortic stiffening that leads to end-organ damage. We examined the cross-sectional association and prospective association of insulin resistance and aortic stiffness in older adults without diabetes. Methods We analyzed 2571 men and women at Visit 5 (in 2011-2013), and 2350 men and women at repeat examinations from baseline at Visit 1 (in 1987-1989) to Visit 5 (in 2011-2013). Linear regression was used to estimate the difference in aortic stiffness per standard unit of HOMA-IR, TG/HDL-C, and TyG at Visit 5. Linear mixed effects were used to assess if high, as opposed to non-high, aortic stiffness (> 75th percentile) was preceded by a faster annual rate of change in log-HOMA-IR, log-TG/HDL-C, and log-TyG from Visit 1 to Visit 5. Results The mean age of participants was 75 years, 37% (n = 957) were men, and 17% (n = 433) were African American. At Visit 5, higher HOMA-IR, higher TG/HDL-C, and higher TyG were associated with higher aortic stiffness (16 cm/s per SD (95% CI 6, 27), 29 cm/s per SD (95% CI 18, 40), and 32 cm/s per SD (95% CI 22, 42), respectively). From Visit 1 to Visit 5, high aortic stiffness, compared to non-high aortic stiffness, was not preceded by a faster annual rate of change in log-HOMA-IR from baseline to 9 years (0.030 (95% CI 0.024, 0.035) vs. 0.025 (95% CI 0.021, 0.028); p = 0.15) or 9 years onward (0.011 (95% CI 0.007, 0.015) vs. 0.011 (95% CI 0.009, 0.013); p = 0.31); in log-TG/HDL-C from baseline to 9 years (0.019 (95% CI 0.015, 0.024) vs. 0.024 (95% CI 0.022, 0.026); p = 0.06) or 9 years onward (- 0.007 (95% CI - 0.010, - 0.005) vs. - 0.009 (95% CI - 0.010, - 0.007); p = 0.08); or in log-TyG from baseline to 9 years (0.002 (95% CI 0.002, 0.003) vs. 0.003 (95% CI 0.003, 0.003); p = 0.03) or 9 years onward (0 (95% CI 0, 0) vs. 0 (95% CI 0, 0); p = 0.08). Conclusions Among older adults without diabetes, insulin resistance was associated with aortic stiffness, but the putative role of insulin resistance in aortic stiffness over the life course requires further study.
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页数:9
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