New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts

被引：3
|
作者：
Shen, Cheng [1 ]
Chen, Xuanming [2 ,3 ]
Xiao, Kai [2 ,3 ]
Che, Guowei [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Thorac Surg, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Sch Med, Chengdu, Peoples R China
[3] Sichuan Kangcheng Biotechnol Co Ltd, Chengdu, Peoples R China
来源：
THORACIC CANCER | 2020年 / 11卷 / 06期
关键词：
BNIP3; cancer-associated fibroblasts; caveolin-1; E2F1; mitophagy;
D O I：
10.1111/1759-7714.13408
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent years, studies have found that E2F1, a downstream effector of caveolin-1 (Cav-1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1-MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradigm for regulation of the tumor cell metabolic reprogramming pathway by Cav-1 that is operationally linked and mutually dependent on the transcriptional activation of E2F1 and induces mitophagy with BNIP3 in cancer-associated fibroblasts (CAFs).
引用
收藏
页码：1369 / 1371
页数：3
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