Molecular Determinants of Radiation Response in Non-Small Cell Lung Cancer

被引：9

作者：

Yom, Sue S. ^{[1
]}

Diehn, Maximilian ^{[2
,3
]}

Raben, David ^{[4
]}

机构：

[1] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA

[2] Stanford Univ, Dept Radiat Oncol, Stanford Canc Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[4] Univ Colorado Hlth, Dept Radiat Oncol, Aurora, CO 80045 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2015年 / 25卷 / 02期

关键词：

GROWTH-FACTOR RECEPTOR; PHASE-I COMBINATION; POLY(ADP-RIBOSE) POLYMERASE; THORACIC RADIATION; CLINICAL-TRIAL; BREAST-CANCER; TGF-BETA; SYNTHETIC LETHALITY; NEGATIVE REGULATION; IONIZING-RADIATION;

D O I：

10.1016/j.semradonc.2014.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that respond rapidly to selective inhibitors. In addition, new approaches to disrupting DNA repair and inflammation and activation of the immune system are being explored. A key question in the field is whether therapeutic multimodality options incorporating radiation therapy can capitalize on the gains made in systemic therapy. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：67 / 77

页数：11

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