Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution

被引:147
|
作者
Weinmayr, Gudrun [1 ,2 ]
Hennig, Frauke [1 ]
Fuks, Kateryna [1 ]
Nonnemacher, Michael [3 ]
Jakobs, Hermann [4 ]
Moehlenkamp, Stefan [5 ]
Erbel, Raimund [5 ]
Joeckel, Karl-Heinz [3 ]
Hoffmann, Barbara [1 ,2 ]
Moebus, Susanne [3 ]
机构
[1] Leibniz Res Inst Environm Med, IUF, Dusseldorf, Germany
[2] Univ Dusseldorf, Sch Med, Dusseldorf, Germany
[3] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany
[4] Univ Cologne, Rhenish Inst Environm Res, D-50931 Cologne, Germany
[5] Univ Duisburg Essen, West German Heart Ctr Essen, Dept Cardiol, Essen, Germany
关键词
Type; 2; diabetes; Particulate matter; PM10; PM2.5; Air pollution; Traffic; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; RISK-FACTORS; INFLAMMATION; PREVALENCE; ASSOCIATION; MORTALITY; DISEASES; IMPACT;
D O I
10.1186/s12940-015-0031-x
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixture. We investigate the long-term effect of traffic-specific and total particulate matter (PM) and road proximity on cumulative incidence of diabetes mellitus (mainly type 2) in a large German cohort. Methods: We followed prospectively 3607 individuals without diabetes at baseline (2000-2003) from the Heinz Nixdorf Recall Study in Germany (mean follow-up time 5.1 years). Mean annual exposures to total as well as traffic-specific PM10 and PM2.5 at residence were estimated using a chemistry transport model (EURAD, 1 km(2) resolution). Effect estimates for an increase of 1 mu g/m(3) in PM were obtained with Poisson regression adjusting for sex, age, body mass index, lifestyle factors, area-level and individual-level socio-economic status, and city. Results: 331 incident cases developed. Adjusted RRs for total PM10 and PM2.5 were 1.05 (95 %-CI: 1.00; 1.10) and 1.03 (95 %-CI: 0.95; 1.12), respectively. Markedly higher point estimates were found for local traffic-specific PM with RRs of 1.36 (95 %-CI: 0.98; 1.89) for PM10 and 1.36 (95 %-CI: 0.97; 1.89) for PM2.5. Individuals living closer than 100 m to a busy road had a more than 30 % higher risk (1.37; 95 %-CI: 1.04; 1.81) than those living further than 200 m away. Conclusions: Long-term exposure to total PM increases type two diabetes risk in the general population, as does living close to a major road. Local traffic-specific PM was related to higher risks for type two diabetes than total PM.
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页数:8
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