N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

被引：38

作者：

Connolly, PJ ^{[1
]}

Wetter, SK ^{[1
]}

Beers, KN ^{[1
]}

Hamel, SC ^{[1
]}

Chen, RHK ^{[1
]}

Wachter, MP ^{[1
]}

Ansell, J ^{[1
]}

Singer, MM ^{[1
]}

Steber, M ^{[1
]}

Ritchie, DM ^{[1
]}

Argentieri, DC ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00117-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (la and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：979 / 984

页数：6

共 50 条

[31] Studies on 5-lipoxygenase inhibitors. I. Synthesis and 5-lipoxygenase-inhibitory activity of novel hydroxamic acid derivatives
Yatabe, T
Kawai, Y
Oku, T
Tanaka, H
CHEMICAL & PHARMACEUTICAL BULLETIN, 1998, 46 (06) : 966 - 972
[32] 5-lipoxygenase inhibitors
不详
DRUG DISCOVERY TODAY, 1997, 2 (06) : 248 - 249
[33] Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
Klegeris, A
McGeer, PL
NEUROBIOLOGY OF AGING, 2002, 23 (05) : 787 - 794
[34] 3,4-DIHYDROXYCHALCONES AS POTENT 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS
SOGAWA, S
NIHRO, Y
UEDA, H
IZUMI, A
MIKI, T
MATSUMOTO, H
SATOH, T
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (24) : 3904 - 3909
[35] Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors
Sud'ina, G. F.
Pushkareva, M. A.
Shephard, P.
Klein, T.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2008, 78 (02): : 99 - 108
[36] PIPERAZINEALKANOL ESTER DERIVATIVES OF INDOMETHACIN AS DUAL INHIBITORS OF 5-LIPOXYGENASE AND CYCLOOXYGENASE
YAMAWAKI, I
SUZUKI, M
OGAWA, K
CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (04) : 963 - 971
[37] BENZYLIDENETHIAZOLIDINONES AS DUAL INHIBITORS OF CYCLOOXYGENASE AND 5-LIPOXYGENASE - POTENTIAL ANTIINFLAMMATORY AGENTS
SORENSON, RJ
CETENKO, WA
CONNOR, DT
DYER, RD
BORNEMEIER, DA
KUIPERS, PJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 141 - MEDI
[38] N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase
Audouin, C
Mestdagh, N
Lassoie, MA
Houssin, R
Hénichart, JP
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (06) : 845 - 848
[39] Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase
Schneider, I
Bucar, F
PHYTOTHERAPY RESEARCH, 2005, 19 (02) : 81 - 102
[40] Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2
Schneider, Claus
Boeglin, William E.
Yin, Huiyong
Stec, Donald F.
Voehler, Markus
Journal of the American Chemical Society, 2006, 128 (03): : 720 - 721

← 1 2 3 4 5 →