N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

被引：38

作者：

Connolly, PJ ^{[1
]}

Wetter, SK ^{[1
]}

Beers, KN ^{[1
]}

Hamel, SC ^{[1
]}

Chen, RHK ^{[1
]}

Wachter, MP ^{[1
]}

Ansell, J ^{[1
]}

Singer, MM ^{[1
]}

Steber, M ^{[1
]}

Ritchie, DM ^{[1
]}

Argentieri, DC ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00117-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (la and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：979 / 984

页数：6

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