Long-Acting Muscarinic Antagonists for Difficult-to-Treat Asthma: Emerging Evidence and Future Directions
被引:4
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作者:
Bulkhi, Adeeb
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USA
Umm Al Qura Univ, Coll Med, Dept Internal Med, Mecca, Saudi ArabiaUniv S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USA
Bulkhi, Adeeb
[1
,2
]
Tabatabaian, Farnaz
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USAUniv S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USA
Tabatabaian, Farnaz
[1
]
Casale, Thomas B.
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USAUniv S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USA
Casale, Thomas B.
[1
]
机构:
[1] Univ S Florida, Dept Internal Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd,MDC 19, Tampa, FL 33612 USA
[2] Umm Al Qura Univ, Coll Med, Dept Internal Med, Mecca, Saudi Arabia
Asthma is a complex disease where many patients remain symptomatic despite guideline-directed therapy. This suggests an unmet need for alternative treatment approaches. Understanding the physiological role of muscarinic receptors and the parasympathetic nervous system in the respiratory tract will provide a foundation of alternative therapeutics in asthma. Currently, several long-acting muscarinic antagonists (LAMAs) are on the market for the treatment of respiratory diseases. Many studies have shown the effectiveness of tiotropium, a LAMA, as add-on therapy in uncontrolled asthma. These studies led to FDA approval for tiotropium use in asthma. In this review, we discuss how the neurotransmitter acetylcholine itself contributes to inflammation, bronchoconstriction, and remodeling in asthma. We further describe the current clinical studies evaluating LAMAs in adult and adolescent patients with asthma, providing a comprehensive review of the current known physiological benefits of LAMAs in respiratory disease.
机构:
Yokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, Japan
Horita, Nobuyuki
Nagashima, Akimichi
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Yokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, Japan
Nagashima, Akimichi
Kaneko, Takeshi
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Yokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pulmonol, Yokohama, Kanagawa 2360004, Japan
Kaneko, Takeshi
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION,
2017,
318
(13):
: 1274
-
1275
机构:
Natl Jewish Hlth, Natl Jewish Hlth Cohen Family Asthma Inst, 1400 Jackson St, Denver, CO 80206 USANatl Jewish Hlth, Natl Jewish Hlth Cohen Family Asthma Inst, 1400 Jackson St, Denver, CO 80206 USA