H3K27 positive diffuse midline glioma. Report of one case

被引：0

作者：

Araneda, Patricia ^{[1
]}

Sujima, Emi ^{[1
,2
]}

Paredes-Manzo, Patricio ^{[3
]}

Vallejo, Rodrigo ^{[4
]}

Valdivia, Felipe ^{[4
]}

Sinning, Mariana ^{[1
,2
]}

Gallegos, Marcela ^{[5
]}

Fuller, Gregory ^{[6
]}

机构：

[1] Clin Alemana, Dept Neurol Psiquiatria, Santiago, Chile

[2] Clin Alemana, Dept Oncol, Santiago, Chile

[3] Clin Alemana, Dept Imagenol, Santiago, Chile

[4] Clin Alemana, Dept Cirugia, Santiago, Chile

[5] Clin Alemana, Dept Lab Clin, Banco Sangre & Anat Patol, Santiago, Chile

[6] MD Anderson Canc Ctr, Dept Pathol, Houston, TX USA

来源：

REVISTA MEDICA DE CHILE | 2019年 / 147卷 / 11期

关键词：

Astrocytoma; Glioma; Histones;

D O I：

10.4067/s0034-98872019001101487

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.

引用

页码：1487 / 1490

页数：4

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