H3K27 positive diffuse midline glioma. Report of one case

被引：0

作者：

Araneda, Patricia ^{[1
]}

Sujima, Emi ^{[1
,2
]}

Paredes-Manzo, Patricio ^{[3
]}

Vallejo, Rodrigo ^{[4
]}

Valdivia, Felipe ^{[4
]}

Sinning, Mariana ^{[1
,2
]}

Gallegos, Marcela ^{[5
]}

Fuller, Gregory ^{[6
]}

机构：

[1] Clin Alemana, Dept Neurol Psiquiatria, Santiago, Chile

[2] Clin Alemana, Dept Oncol, Santiago, Chile

[3] Clin Alemana, Dept Imagenol, Santiago, Chile

[4] Clin Alemana, Dept Cirugia, Santiago, Chile

[5] Clin Alemana, Dept Lab Clin, Banco Sangre & Anat Patol, Santiago, Chile

[6] MD Anderson Canc Ctr, Dept Pathol, Houston, TX USA

来源：

REVISTA MEDICA DE CHILE | 2019年 / 147卷 / 11期

关键词：

Astrocytoma; Glioma; Histones;

D O I：

10.4067/s0034-98872019001101487

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.

引用

页码：1487 / 1490

页数：4

共 50 条

[1] Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered
Griessmair, Michael
Delbridge, Claire
Zimmer, Claus
Mayr, Eva
Wagner, Arthur
Canisius, Julian
Metz, Marie-Christin
Wiestler, Benedikt
FRONTIERS IN ONCOLOGY, 2025, 15
[2] H3K27M mutant diffuse midline glioma: a case report
Luo, Y.
Zeng, L.
Xie, X-Q
Wang, F.
Liu, Y-Z
Kang, J-B
Li, X-F
Wu, D-B
Qu, B-L
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (05) : 2579 - 2584
[3] Targeting H3K27 Mutant Diffuse Midline Glioma Via Glucosylceramide Synthase Inhibitors
Paret, C.
Sandhoff, R.
ElMalki, K.
Wingerter, A.
Zahnreich, S.
Frauenknecht, K.
Lehmann, N.
Alexandra, R.
Moisch, M.
Faber, J.
PEDIATRIC BLOOD & CANCER, 2021, 68 : S115 - S115
[4] Diffuse Midline Glioma, H3 K27M-Mutant: A Case Report
Rodriguez Leon, Jose
Perez Berenguer, Juan
Morales Vargas, Bryan
Rivera Roman, Keila
Vigo Prieto, Juan
Labat Alvarez, Eduardo
Ferrer Torres, Luis
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2018, 150 : S34 - S34
[5] Diffuse midline glioma H3K27M mutation in adult: A case report
Bhattarai, Ayush Mohan
Mainali, Gaurab
Jha, Pinky
Karki, Pearlbiga
Adhikari, Abhishek
Pandit, Ayushma
Bhattarai, Ashish Mohan
ANNALS OF MEDICINE AND SURGERY, 2022, 76
[6] Intraventricular H3K27-Altered Diffuse Midline Glioma in Lateral Ventricle: A Case Report
Kwok, P. l
Lui, Y. h
Chin, H. k
Ho, L. y
Chan, S. k
Chu, C. y
HONG KONG JOURNAL OF RADIOLOGY, 2024, 27 (01): : e39 - e42
[7] A case of diffuse midline glioma, H3 K27M-mutant
Kyriakopoulos, G.
Anagnostopoulos, C.
Boskos, C.
Korfias, S.
Stranjalis, G.
Razis, E.
Argyrakos, T.
VIRCHOWS ARCHIV, 2017, 471 : S219 - S219
[8] Case N○1: Diffuse midline glioma, H3K27-altered
Varlet, Pascale
ANNALES DE PATHOLOGIE, 2022, 42 (05) : 383 - 385
[9] Positive H3K27M cytology in cerebrospinal fluid in diffuse midline glioma
Kawai, Honami
Hattori, Takaaki
Nakajima, Yutaka
Yokota, Takanori
Onishi, Iichiroh
NEUROLOGICAL SCIENCES, 2025, 46 (03) : 1451 - 1453
[10] GLUCOSYLCERAMIDE SYNTHASE INHIBITORS INDUCE CERAMIDE ACCUMULATION AND SENSITISE H3K27 MUTANT DIFFUSE MIDLINE GLIOMA TO IRRADIATION
Paret, Claudia
Sandhoff, Roger
Zahnreich, Sebastian
Wehling, Pia Charlotte
El Malki, Khalifa
Faber, Joerg
NEURO-ONCOLOGY, 2022, 24 : 28 - 28

← 1 2 3 4 5 →