Polar Alkaloids from the Caribbean Marine Sponge Niphates digitalis

被引：0

作者：

Regalado, Erik L. ^{[1
]}

Mendiola, Judith ^{[2
]}

Laguna, Abilio ^{[1
]}

Nogueiras, Clara ^{[3
]}

Thomas, Olivier P. ^{[4
]}

机构：

[1] Ctr Marine Bioprod CEB1MAR, Dept Chem, Havana 10400, Cuba

[2] Inst Trop Med Pedro Kouri IPK, Dept Parasitol, Havana, Cuba

[3] Univ Havana, Ctr Nat Prod, Fac Chem, Havana 10400, Cuba

[4] Univ Nice Sophia Antipolis, Lab Chim Mol Bioact & Aromes, CNRS,Inst Chim Nice, Fac Sci,UMR 6001, F-06108 Nice, France

来源：

NATURAL PRODUCT COMMUNICATIONS | 2010年 / 5卷 / 08期

关键词：

Marine sponge; Niphates digitalis; nucleosides; nucleobases; antimalarial activity; cytotoxicity; MALARIA PARASITES; NUCLEOSIDES; METABOLITES; PRODUCTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

引用

页码：1187 / 1190

页数：4

共 50 条

[21] 2 STEROIDAL ALKALOIDS FROM A MARINE SPONGE, PLAKINA SP
ROSSER, RM
FAULKNER, DJ
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (26): : 5157 - 5160
[22] Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
Kusama, Taishi
Tanaka, Naonobu
Takahashi-Nakaguchi, Azusa
Gonoi, Tohru
Fromont, Jane
Kobayashi, Jun'ichi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2014, 62 (05) : 499 - 503
[23] Dibromopyrrole Alkaloids from the Marine Sponge Acanthostylotella sp.
Ebada, Sherif Saeed
Edrada-Ebel, RuAngelie
de Voogd, Nicole J.
Wray, Victor
Proksch, Peter
NATURAL PRODUCT COMMUNICATIONS, 2009, 4 (01) : 47 - 52
[24] New diterpene alkaloids from the marine sponge Agelas mauritiana
Hong, Li-Li
Sun, Jia-Bao
Yang, Fan
Liu, Man
Tang, Jie
Sun, Fan
Jiao, Wei-Hua
Wang, Shu-Ping
Zhang, Wei
Lin, Hou-Wen
RSC ADVANCES, 2017, 7 (39): : 23970 - 23976
[25] Bioactive Guanidine Alkaloids from Two Caribbean Marine Sponges
Laville, Remi
Thomas, Olivier P.
Berrue, Fabrice
Marquez, Diana
Vacelet, Jean
Amade, Philippe
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (09): : 1589 - 1594
[26] Isolation and X-ray crystal structure of racemic xestospongin D from the Singapore marine sponge Niphates sp
Pettit, GR
Orr, B
Herald, DL
Doubek, DL
Tackett, L
Schmidt, JM
Boyd, MR
Pettit, RK
Hooper, JNA
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (12) : 1313 - 1318
[27] Euryjanicin A: a new cycloheptapeptide from the Caribbean marine sponge Prosuberites laughlini
Vicente, Jan
Vera, Brunilda
Rodriguez, Abimael D.
Rodriguez-Escudero, Idaliz
Raptis, Raphael G.
TETRAHEDRON LETTERS, 2009, 50 (32) : 4571 - 4574
[28] ANTIPARASITIC BROMOTYROSINE DERIVATIVES FROM THE CARIBBEAN MARINE SPONGE Aiolochroia crassa
Galeano, Elkin
Martinez, Alejandro
Thomas, Olivier P.
Robledo, Sara
Munoz, Diana
QUIMICA NOVA, 2012, 35 (06): : 1189 - 1193
[29] New bromopyrrole alkaloids from the marine sponge Agelas sp.
Sun, Ya-Ting
Lin, Bin
Li, Sheng-Ge
Liu, Man
Zhou, Yong Jun
Xu, Ying
Hua, Hui-Ming
Lin, Hou-Wen
TETRAHEDRON, 2017, 73 (19) : 2786 - 2792
[30] MANZAMINES, NOVEL ANTITUMOR ALKALOIDS FROM A MARINE SPONGE, HALICLONA SP
SAKAI, R
HIGA, T
JEFFORD, CW
BERNARDINELLI, G
KOHMOTO, S
JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S198 - S198

← 1 2 3 4 5 →