Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

被引：295

作者：

Ryall, Scott ^{[1
,2
]}

Zapotocky, Michal ^{[1
,3
,4
,5
]}

Fukuoka, Kohei ^{[1
,3
]}

Nobre, Liana ^{[1
,3
]}

Stucklin, Ana Guerreiro ^{[1
,3
,6
]}

Bennett, Julie ^{[1
,3
]}

Siddaway, Robert ^{[1
]}

Li, Christopher ^{[1
,2
]}

Pajovic, Sanja ^{[1
]}

Arnoldo, Anthony ^{[7
]}

Kowalski, Paul E. ^{[7
]}

Johnson, Monique ^{[7
]}

Sheth, Javal ^{[1
,7
]}

Lassaletta, Alvaro ^{[1
,3
,8
]}

Tatevossian, Ruth G. ^{[9
]}

Orisme, Wilda ^{[9
]}

Qaddoumi, Ibrahim ^{[10
]}

Surrey, Lea F. ^{[11
,12
]}

Li, Marilyn M. ^{[11
]}

Waanders, Angela J. ^{[12
,13
,14
,15
]}

Gilheeney, Stephen ^{[16
]}

Rosenblum, Marc ^{[17
]}

Bale, Tejus ^{[17
]}

Tsang, Derek S. ^{[18
,19
]}

Laperriere, Normand ^{[18
,19
]}

Kulkarni, Abhaya ^{[20
,21
]}

Ibrahim, George M. ^{[20
,21
]}

Drake, James ^{[20
,21
]}

Dirks, Peter ^{[1
,2
,21
]}

Taylor, Michael D. ^{[1
,2
,21
]}

Rutka, James T. ^{[1
,2
,21
]}

Laughlin, Suzanne ^{[22
,23
]}

Shroff, Manohar ^{[22
,23
]}

Shago, Mary ^{[2
,7
]}

Hazrati, Lili-Naz ^{[2
,24
]}

D'Arcy, Colleen ^{[2
,24
,25
]}

Ramaswamy, Vijay ^{[1
,3
,26
]}

Bartels, Ute ^{[3
,26
]}

Huang, Annie ^{[1
,2
,3
]}

Bouffet, Eric ^{[3
,26
]}

Karajannis, Matthias A. ^{[16
]}

Santi, Mariarita ^{[11
,12
]}

Ellison, David W. ^{[9
]}

Tabori, Uri ^{[1
,3
,27
]}

Hawkins, Cynthia ^{[1
,2
,24
]}

机构：

[1] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Hosp Sick Children, Dept Haematol Oncol, Toronto, ON, Canada

[4] Charles Univ Prague, Fac Med 2, Prague, Czech Republic

[5] Univ Hosp Moto, Prague, Czech Republic

[6] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland

[7] Hosp Sick Children, Dept Paediat Lab Med, Toronto, ON, Canada

[8] Hosp Univ Nino Jesus, Dept Pediat Hematol & Oncol, Madrid, Spain

[9] St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA

[10] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[11] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[12] Childrens Hosp Philadelphia, Dept Genom Diagnost, Philadelphia, PA 19104 USA

[13] Childrens Hosp Philadelphia, Ctr Data Driven Discovery Biomed, Philadelphia, PA 19104 USA

[14] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA

[15] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA

[16] Mem Sloan Kettering Canc Ctr, Dept Pediat, 1275 York Ave, New York, NY 10021 USA

[17] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[18] Univ Hlth Network, Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON, Canada

[19] Univ Toronto, Fac Med, Dept Radiat Oncol, Toronto, ON, Canada

[20] Univ Toronto, Dept Surg, Toronto, ON, Canada

[21] Hosp Sick Children, Dept Neurosurg, Toronto, ON, Canada

[22] Hosp Sick Children, Dept Radiol, Toronto, ON, Canada

[23] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[24] Hosp Sick Children, Dept Pathol, Toronto, ON, Canada

[25] Alfred Hosp, Dept Anat Pathol, Prahran, Vic, Australia

[26] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[27] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

CANCER CELL | 2020年 / 37卷 / 04期

基金：

加拿大健康研究院;

关键词：

INTRINSIC PONTINE GLIOMA; MAPK PATHWAY ACTIVATION; GENETIC ALTERATIONS; GENOMIC ANALYSIS; NERVOUS-SYSTEM; IDH2; MUTATIONS; BRAF; TUMORS; ABERRATIONS; FUSION;

D O I：

10.1016/j.ccell.2020.03.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in their clinical outcome. To address this, we characterized a cohort of >1,000 clinically annotated pLGG. Eighty-four percent of cases harbored a driver alteration, while those without an identified alteration also often exhibited upregulation of the RAS/MAPK pathway. pLGG could be broadly classified based on their alteration type. Rearrangement-driven tumors were diagnosed at a younger age, enriched for WHO grade I histology, infrequently progressed, and rarely resulted in death as compared with SNV-driven tumors. Further sub-classification of clinical-molecular correlates stratified pLGG into risk categories. These data highlight the biological and clinical differences between pLGG subtypes and opens avenues for future treatment refinement.

引用

页码：569 / +

页数：20

共 50 条

[41] Trametinib for progressive pediatric low-grade gliomas
Kondyli, Maria
Larouche, Valerie
Saint-Martin, Christine
Ellezam, Benjamin
Pouliot, Lauranne
Sinnett, Daniel
Legault, Genevieve
Crevier, Louis
Weil, Alex
Farmer, Jean-Pierre
Jabado, Nada
Perreault, Sebastien
JOURNAL OF NEURO-ONCOLOGY, 2018, 140 (02) : 435 - 444
[42] RESPONSE OF PEDIATRIC LOW-GRADE GLIOMAS TO CHEMOTHERAPY
GAJJAR, A
HEIDEMAN, RL
KOVNAR, EH
LANGSTON, JA
SANFORD, RA
DOUGLASS, EC
JENKINS, JJ
HOROWITZ, ME
KUN, LE
PEDIATRIC NEUROSURGERY, 1993, 19 (03) : 113 - 120
[43] Chemotherapy in pediatric low-grade gliomas (PLGG)
Lassaletta, Alvaro
Zapotocky, Michal
Bouffet, Eric
CHILDS NERVOUS SYSTEM, 2024, 40 (10) : 3229 - 3239
[44] Integrated analysis of pediatric low-grade glioma: clinical implications and the path forward
Packer, Roger J.
MacDonald, Tobey J.
NEURO-ONCOLOGY, 2020, 22 (10) : 1413 - 1414
[45] CLINICAL AND MOLECULAR CHARACTERIZATION OF METASTATIC PEDIATRIC LOW GRADE GLIOMAS
Lindsay, Holly
Stuckert, Austin
Chintagumpala, Murali
Su, Jack
Baxter, Patricia
Okcu, M. Fatih
Malbari, Fatema
Rednam, Surya
Reuther, Jacquelyn
Fisher, Kevin
Scollon, Sarah
Plon, Sharon
Roy, Angshumoy
Parsons, D. Will
Lin, Frank
NEURO-ONCOLOGY, 2022, 24 : 87 - 87
[46] MRI radiomics analysis of molecular alterations in low-grade gliomas
Shofty, Ben
Artzi, Moran
Ben Bashat, Dafna
Liberman, Gilad
Haim, Oz
Kashanian, Alon
Bokstein, Felix
Blumenthal, Deborah T.
Ram, Zvi
Shahar, Tal
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, 2018, 13 (04) : 563 - 571
[47] GENE EXPRESSION ANALYSIS OF 151 PEDIATRIC LOW-GRADE GLIOMAS REVEALS UNDERLYING MOLECULAR HETEROGENEITY
Bergthold, Guillaume
Bandopadhayay, Pratiti
Rich, Benjamin
Chan, Jennifer
Santagata, Sandro
Hoshida, Yujin
Ramkissoon, Shakti
Ramkissoon, Lori
Golub, Todd
Tabak, Barbara
Ferrer-Luna, Ruben
Weng, Patrick Y.
Stiles, Charles
Grill, Jacques
Kieran, Mark W.
Ligon, Keith L.
Beroukhim, Rameen
NEURO-ONCOLOGY, 2014, 16 : 62 - 62
[48] MRI radiomics analysis of molecular alterations in low-grade gliomas
Ben Shofty
Moran Artzi
Dafna Ben Bashat
Gilad Liberman
Oz Haim
Alon Kashanian
Felix Bokstein
Deborah T. Blumenthal
Zvi Ram
Tal Shahar
International Journal of Computer Assisted Radiology and Surgery, 2018, 13 : 563 - 571
[49] Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas
Grob, Sydney T.
Nobre, Liana
Campbell, Kristen R.
Davies, Kurtis D.
Ryall, Scott
Aisner, Dara L.
Hoffman, Lindsey
Zahedi, Shadi
Morin, Andrew
Crespo, Michele
Nellan, Anandani
Green, Adam L.
Foreman, Nicholas
Vibhakar, Rajeev
Hankinson, Todd C.
Handler, Michael H.
Hawkins, Cynthia
Tabori, Uri
Kleinschmidt-DeMasters, B. K.
Levy, Jean M. Mulcahy
NEURO-ONCOLOGY ADVANCES, 2020, 2 (01)
[50] CLINICAL AND MOLECULAR CHARACTERIZATION OF A MULTI-INSTITUTIONAL COHORT OF PEDIATRIC SPINAL CORD LOW-GRADE GLIOMAS
Grob, Sydney
Nobre, Lianna
Davies, Kurtis
Ryall, Scott
Aisner, Dara
Hoffman, Lindsey
Zahedi, Shadi
Morin, Andrew
Nellan, Anandani
Green, Adam
Foreman, Nicholas
Vibhakar, Rajeev
Hankinson, Todd
Handler, Michael
Hawkins, Cynthia
Tabori, Uri
Kleinschmidt-DeMasters, B. K.
Levy, Jean Mulcahy
NEURO-ONCOLOGY, 2020, 22 : 373 - 373

← 1 2 3 4 5 →