The membrane effect of Benfluron: Modulation of the heart sarcolemmal (Na+, K+)-ATPase and Mg2+-ATPase activities

被引：0
|
作者：
Dzurba, A [1 ]
Vrbjar, N [1 ]
Breier, A [1 ]
Ziegelhoffer, A [1 ]
机构：
[1] SLOVAK ACAD SCI,INST MOLEC PHYSIOL & GENET,BRATISLAVA 83334,SLOVAKIA
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 1996年 / 15卷 / 01期
关键词：
Benfluron(R); (Na+; K+)-ATPase; heart sarcolemma;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of Benfluron(R) on the heart sarcolemmal (Na+, K+)-ATPase and Mg2+-ATPase activities was studied in crude membrane fraction as well as in purified sarcolemmal membranes isolated from rat heart. Benfluron in concentration range 10(-7) - 5 . 10(-5) mol.l(-1) did not exert any effect on ATPase activities studied. 10(-4) mol.l(-1) Benfluron was stimulatory towards (Na+, K+)-ATPase, while Mg2+-ATPase activity was depressed. Kinetic analysis of interaction of Benfluron with (Na+, K+)-ATPase revealed an increase in the V-max and decrease in the K-m values for ATP. The possible mechanism of interaction of the drug with (Na+, K+)-ATPase is discussed.
引用
收藏
页码：71 / 75
页数：5
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