Antimicrobial compounds from the Australian desert plant Eremophild neglecta

被引:42
|
作者
Ndi, Chi P.
Semple, Susan J.
Griesser, Hans J.
Pyke, Simon M.
Barton, Mary D.
机构
[1] Univ S Australia, Sch Pharm & Med Sci, Sansom Inst, Adelaide, SA 5000, Australia
[2] Univ S Australia, Ian Wark Res Inst, Mawson Lakes, SA 5095, Australia
[3] Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5000, Australia
来源
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 09期
关键词
D O I
10.1021/np070180r
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A crude extract from the Australian desert plant Eremophila neglecta has recently been shown to possess antibacterial activity in a survey of candidate plants that may bear novel antimicrobial compounds. Bioassay-directed fractionation of the Et2O extract of E. neglecta using a broth microdilution assay led to the isolation of three new serrulatane-type diterpenoids, 2,19-diacetoxy-8-hydroxyserrulat-14-ene (2), 8,19-dihydroxyserrulat-14-ene (3), and 8-hydroxyserrulat-14-en-19-oic acid (4), and a known o-naphthoquinone commonly referred to as biflorin (5). The structures of 2-5 were determined using 1D and 2D NMR, FTIR, and high-resolution mass spectrometry. Compounds 3-5 showed antimicrobial activity against Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, and S. pneumoniae. The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) ranged from 6.5 to 101.6 mu M and 12.7 to 202.9 mu M, respectively. No activity was observed for these compounds against Gram-negative bacteria.
引用
收藏
页码:1439 / 1443
页数:5
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