High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

被引：81
|
作者：
Kim, DJ
Roh, S
Kim, Y [1 ]
Yoon, SJ
Lee, HK
Han, CS
Kim, YK [1 ]
机构：
[1] Korea Univ, Coll Med, Dept Psychiat, Seoul 136701, South Korea
[2] Catholic Univ Korea, Korea Univ, Ansan Hosp, Coll Med,Dept Psychiat, Seoul 425020, South Korea
[3] Hanyang Univ, Coll Med, Dept Neuropsychiat, Seoul 133791, South Korea
来源：
NEUROSCIENCE LETTERS | 2005年 / 388卷 / 02期
关键词：
BDNF; methamphetamine; ELISA; dopamine; neurotoxicity;
D O I：
10.1016/j.neulet.2005.06.042
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：112 / 115
页数：4
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